Three dimensional MRF obtains highly repeatable and reproducible multi-parametric estimations in the healthy human brain at 1.5T and 3T

Magnetic resonance fingerprinting (MRF) is highly promising as a quantitative MRI technique due to its accuracy, robustness, and efficiency. Previous studies have found high repeatability reproducibility of 2D MRF acquisitions in the brain. Here, we extended our investigations 3D covering whole brain using spiral projection k-space trajectories. Our travelling head study acquired test/retest data from brains 12 healthy volunteers 8 systems (3 at 3 T 5 1.5 T, all single vendor), design not requiring subjects be scanned sites. The pulse sequence reconstruction algorithm were same for acquisitions. After registration MRF-derived PD T1 T2 maps an anatomical atlas, coefficients variation (CVs) computed assess inter-site each voxel, while General Linear Model (GLM) was used determine voxel-wise variability between confounders, which included test/retest, subject, field strength site. analysis demonstrated (CVs 0.7–1.3% T1, 2.0–7.8% T2, 1.4–2.5% normalized PD) 2.0–5.8% 7.4–10.2% 5.2–9.2% gray white matter. Both improved when compared similar experiments Three-dimensional obtains repeatable reproducible estimations supporting translation MRF-based fast imaging into clinical applications.